A calm river with clear water, surrounded by dense trees and rocky banks.

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Our top choices for O Brien hotels

1. Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
2.0 star property
Lake City
7.0 out of 10, Good, (1,000 reviews)
"Nice and restful place to stay"
United States
Frederick
The price is CA $89
CA $100 total
includes taxes & fees
Jul 5 - Jul 6
Days Inn by Wyndham Lake City I-10

2. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (729 reviews)
"The room was clean, staff were very nice and the breakfast was outstanding."
United States
Michelle
The price is CA $93
CA $104 total
includes taxes & fees
Jul 21 - Jul 22
Super 8 by Wyndham Lake City

3. Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.6 out of 10, Good, (626 reviews)
"REALLY NICE PLACE, VERY CLEAN, WONDERFUL STAFF"
United States
Caroline
The price is CA $92
CA $103 total
includes taxes & fees
Jun 22 - Jun 23
Palms Garden Inn

4. Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
7.6 out of 10, Good, (193 reviews)
"Clean room hot water nice upgrades and friendly staff"
United States
Pennee
The price is CA $88
CA $99 total
includes taxes & fees
Jun 22 - Jun 23
Motel 6 – Lake City, Fl – Medical Center

5. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,002 reviews)
"We stopped for one night. We have stayed here before when visiting. The staff is always helpful and accommodating ."
United States
William
The price is CA $101
CA $113 total
includes taxes & fees
Jun 22 - Jun 23
Americas Best Value Inn Lake City

6. Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.0 out of 10, Very good, (1,001 reviews)
"It was clean and comfortable bed !"
United States
Glenda
The price is CA $106
CA $119 total
includes taxes & fees
Jul 5 - Jul 6
Quality Inn Lake City

7. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,004 reviews)
"The staff were amazing, great location, big rooms, great breakfast"
United States
Brittani
The price is CA $147
CA $166 total
includes taxes & fees
Jul 12 - Jul 13
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

8. Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,003 reviews)
"Great stay - easy - accommodating - quiet!"
United States
Paula
The price is CA $151
CA $170 total
includes taxes & fees
Jul 5 - Jul 6
Comfort Suites Lake City

9. Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,059 reviews)
"The location was great have many restaurants around, and the staff was very friendly"
United States
Carla
The price is CA $134
CA $151 total
includes taxes & fees
Jun 22 - Jun 23
Best Western Plus Lake City

10. Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (522 reviews)
"Wonderful place to stay"
United States
Tamela
The price is CA $150
CA $168 total
includes taxes & fees
Jul 2 - Jul 3
Hampton Inn & Suites Alachua I-75

11. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,002 reviews)
"Great for a short stay and clean"
United States
Brizheet
The price is CA $95
CA $107 total
includes taxes & fees
Jul 5 - Jul 6
Days Inn by Wyndham Lake City I-75

12. Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,003 reviews)
"Clean helpful staff and breakfast was good.parking good also"
United States
John
The price is CA $154
CA $174 total
includes taxes & fees
Jul 5 - Jul 6
Tru by Hilton Lake City

13. Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (308 reviews)
"The room was fairly cheap and staff was friendly."
United States
James
The price is CA $109
CA $120 total
includes taxes & fees
Jun 22 - Jun 23
Econo Lodge Live Oak

14. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.0 out of 10, (1,000 reviews)
"Desk & housekeeping staff were super helpful & friendly!"
United States
Cameron
The price is CA $82
CA $92 total
includes taxes & fees
Jun 22 - Jun 23
Baymont by Wyndham Lake City I-75

15. Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very good, (604 reviews)
"Surprisingly well maintained and clean for the price. Lady at the front desk was kind and sweet."
United States
Johnny
The price is CA $88
CA $99 total
includes taxes & fees
Jun 22 - Jun 23
Regal Inn

16. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,004 reviews)
"Breakfast menu was fresh, the room was clean, and the staff friendly and professional."
United States
Claire
The price is CA $161
CA $182 total
includes taxes & fees
Jul 5 - Jul 6
Hampton Inn & Suites Lake City

17. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
White Springs
7.2 out of 10, Good, (676 reviews)
The price is CA $94
CA $104 total
includes taxes & fees
Jun 28 - Jun 29
Quality Inn White Springs Suwanee

18. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
Lake City
8.6 out of 10, Excellent, (1,122 reviews)
"Enjoyed our stay"
United States
Tammie
The price is CA $135
CA $152 total
includes taxes & fees
Jul 1 - Jul 2
La Quinta Inn & Suite by Wyndham Lake City

19. Americas Best Value Inn Alachua

Americas Best Value Inn Alachua
2.0 star property
Alachua
5.0 out of 10, (628 reviews)
"It was a place to stay"
United States
Jennifer
Americas Best Value Inn Alachua

20. The Blanche

The Blanche
2.0 star property
Lake City
9.4 out of 10, Exceptional, (194 reviews)
"Great property! Beautiful renovated!"
United States
Brandi
The price is CA $182
CA $204 total
includes taxes & fees
Jun 23 - Jun 24
The Blanche
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

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Frequently asked questions

What is the best area to stay in O Brien?
The best area to stay in O'Brien, Florida, is along the Suwannee River, particularly around the public boat ramps and access points.

This area is the main draw for visitors to O'Brien, as it provides direct access to the natural beauty and recreational opportunities of the Suwannee River. You'll find a scattering of accommodations, from holiday rentals to small, independent motels, often with direct riverfront access or just a short drive away. This allows for convenient enjoyment of activities like fishing, kayaking, and boating.

Families will find this area particularly appealing due to the easy access to water-based activities. Many properties offer amenities like barbecue areas and space for children to play, making it simple to enjoy the outdoors together. The nearby Spirit of the Suwannee Music Park also hosts various events throughout the year, which can be a fun addition to a family holiday.

For couples looking for a relaxed escape, staying by the river offers a peaceful setting. You can enjoy quiet evenings by the water, explore the river's springs, or simply unwind away from city life.
When is the best time to go to O Brien?
The best time to visit O'Brien, Florida, is typically during the spring (March to May) and autumn (September to November) months.

During these periods, the weather is generally mild and pleasant, with comfortable temperatures, making it ideal for enjoying outdoor activities like swimming, fishing, and exploring the natural springs without the intense heat and humidity of summer or the cooler temperatures of winter. The spring also brings blooming wildflowers, adding to the area's natural beauty.

For couples looking for a relaxing escape, these shoulder seasons offer a good balance of agreeable weather and fewer crowds compared to peak summer. You'll find it easier to enjoy the tranquility of the Ichetucknee Springs State Park or the Suwannee River without feeling overwhelmed by other visitors.

Families travelling with children might also find these times more comfortable for outdoor adventures.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in O Brien.
How can I save on a O Brien hotel booking with Expedia?
Members always get our best prices. Find our best O Brien hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a O Brien hotel?
Prices for hotels in O Brien often vary, but you can find a great deal from CA $61 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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